Dipartimento scienze della vita e biotecnologie

The somatic FAH C.1061C>A change counteracts the frequent FAH c.1062+5G>A mutation and permits U1snRNA-based splicing correction. Scalet D, Sacchetto C, Bernardi F, Pinotti M, van de Graaf SFJ, Balestra D.
J Hum Genet. 2018 May;63(5):683-686.

doi: 10.1038/s10038-018-0427-x

Exploring Splicing-Switching Molecules For Seckel Syndrome Therapy. Scalet D, Balestra D, Rohban S, Bovolenta M, Perrone D, Bernardi F, Campaner S, Pinotti M.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):15-20.

doi: 10.1016/j.bbadis.2016.09.011.

An Exon-Specific U1snRNA Induces a Robust Factor IX Activity in Mice Expressing Multiple Human FIX Splicing Mutants. Balestra D, Scalet D, Pagani F, Rogalska ME, Mari R, Bernardi F, Pinotti M.

Mol Ther Nucleic Acids. 2016 Oct 4;5(10):e370.

doi: 10.1038/mtna.2016.77

Molecular Basis and Therapeutic Strategies to Rescue Factor IX Variants That Affect Splicing and Protein Function. Tajnik M, Rogalska ME, Bussani E, Barbon E, Balestra D, Pinotti M, Pagani F.
PLoS Genet. 2016 May 26;12(5):e1006082.

doi: 10.1371/journal.pgen.1006082

Regulation of a strong F9 cryptic 5'ss by intrinsic elements and by combination of tailored U1snRNAs with antisense oligonucleotides. Balestra D, Barbon E, Scalet D, Cavallari N, Perrone D, Zanibellato S, Bernardi F, Pinotti M.

Hum Mol Genet. 2015 Sep 1;24(17):4809-16

doi: 10.1093/hmg/ddv205

An engineered U1 small nuclear RNA rescues splicing defective coagulation F7 gene expression in mice. Balestra D, Faella A, Margaritis P, Cavallari N, Pagani F, Bernardi F, Arruda VR, Pinotti M.

J Thromb Haemost. 2014 Feb;12(2):177-85.

doi: 10.1111/jth.12471

Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant. Cavallari N, Balestra D, Branchini A, Maestri I, Chuamsunrit A, Sasanakul W, Mariani G, Pagani F, Bernardi F, Pinotti M.

Biochim Biophys Acta. 2012 Jul;1822(7):1109-13.

doi: 10.1016/j.bbadis.2012.03.001

An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects. Fernandez Alanis E, Pinotti M, Dal Mas A, Balestra D, Cavallari N, Rogalska ME, Bernardi F, Pagani F.

Hum Mol Genet. 2012 Jun 1;21(11):2389-98.

doi: 10.1093/hmg/dds045

Rescue of coagulation factor VII function by the U1+5A snRNA. Pinotti M1, Balestra D, Rizzotto L, Maestri I, Pagani F, Bernardi F.

Blood. 2009 Jun 18;113(25):6461-4.

doi: 10.1182/blood-2009-03-207613

U1-snRNA-mediated rescue of mRNA processing in severe factor VII deficiency. Pinotti M, Rizzotto L, Balestra D, Lewandowska MA, Cavallari N, Marchetti G, Bernardi F, Pagani F.

Blood. 2008 Mar 1;111(5):2681-4.

doi: 10.1182/blood-2007-10-117440

Temi di ricerca

Ferraresi Paolo — 2020-04-14T08:25:00Z

Queste le principali tematiche di ricerca nel nostro laboratorio

Corticosterone

Felletti Marcella — 2013-03-06T09:34:37Z

Hormone	Corticosterone
Price x sample	20.00 €
Minimum order	Order of 25 samples or less will be hold until a sufficient number of samples will have been collected. Alternatively, they can be processed immediately for a total of 500.00 €
Sample volume	50 μl serum/plasma
Collection	plastic or glass tube
Storage/Shipment	- 20 C at least
Species	most species; extraction might be required for some species with an additional charge

Link congressi

Bertorelle Giorgio — 2013-01-14T08:57:17Z

bando 2

Bianchi Nicoletta — 2012-11-21T09:52:42Z

Facilities

Fusani Leonida — 2012-05-31T22:00:00Z

Nets

Researchers at the station have access to the net arrays (318 m) of the Ringing Station, which has one of the highest efficiency (capture/net surface) in the Mediterranean region. Daily captures average 600 in late April and May, with peaks of 1200 captures per days. Morphological and physiological data collected by the ringers are available for research projects, as well as specific data collected on request.

Lab space

Limited laboratory space is available for simple operations. Electricity and water are freely available, and there is a refrigerator and a - 18 C freezer for sample storage. In addition, space can be arranged for temporary caging of birds. This needs to be requested well in advance and will involve additional costs.

Accomodation

There are apartments available for rent which can host up to 4 people at 60-80 EUR per day including water and electricity. Apartments are located very close to the Station and within the village, with easy access to shops, restaurants, bank, and public transportation.

About us

Fusani Leonida — 2012-05-31T22:00:00Z

The Ponza Research Station is located on the island of Ponza in the Thyrrenian Sea, about XX miles from the western coast of central Italy. Researchers at the station focus on bird migration. The station operates in close connection with the Ponza Ringing Station, where traditional bird ringing and monitoring acivities are carried out. There is a bidirectional flow between the Research and Ringing programmes, in that the researchers profit from the large mist-nets setup of the Ringing Station which provides very large numbers of birds throughout the migratory season, whereas the Ringing Station receives financial support from the research programmes and provide a stimulating environment for bird ringers who whis to see their work contributing to scientific advances.

Visiting us

Fusani Leonida — 2012-05-16T13:35:00Z

Research application

We welcome researchers from all countries to visit and work at our Station. For a preliminary inquiry, please send an email to leonida.fusani (at) unife.it. Make sure to include details of experimental procedures which require an ethical evaluation. Usually, the Ringing Station operates between March and May. However, we will be happy to consider applications for research outside this period.

Research fees

Both the Research and the Ringing Stations rely completely on external funding for operation. Thus, we need to ask a small fee for using our facilities, in order to be able to continue operations when funding is scarce. The fee is 150 EUR per calendar week, which can be provided as a donation to the CISCA, the no-profit organization (registered charity) that runs the Ringing Station. Additional fees will be applied for special requests, which need to be organized well in advance.

Acknowledgements

All publications resulting from work conducted at the Ponza Research Station should report in the Acknowledgements this text: "This is publication N. XX of the Ponza Research Station". The number to be inserted will be provided by us.

Visiting scientists

Several scientists have conducted research at the Ponza Research Station, including:

-Jacques Balthazart, University of Liege, Belgium

-Ulf Bauchinger, Max Planck Institute for Ornithology, Seewiesen, Germany

-Marco Catoni, Ornis Italica, Rome, Italy

-David Costantini, University of Glasgow, UK

-Scott McWilliams, Rhode Island University, USA

-Marylin Ramenowski, University of California at Davies, USA

-Marjorie Sorensen, University of Cambridge, UK

-John C. Wingfield, University of California at Davies, USA

-Marco Zaccaroni, University of Florence, Italy

Ponza Research Station

Fusani Leonida — 2012-05-16T13:30:00Z

The Ponza Research Station is located on the island of Ponza in the Thyrrenian Sea, about 20 nautical miles (37 km) from the Western coast of central Italy. Researchers at the station focus on bird migration. The station operates in close connection with the Ponza Ringing Station, where traditional bird ringing and monitoring acivities are carried out. There is a bi-directional flow between the Research and Ringing programmes, in that the researchers profit from the large mist-nets setup of the Ringing Station which provides very large numbers of birds throughout the migratory season, whereas the Ringing Station receives financial support from the research programmes and provides a stimulating environment for bird ringers who whis to see their work contributing to scientific advances.

Isole pontine

Fusani Leonida — 2012-05-16T13:29:18Z

Images

Fusani Leonida — 2012-05-16T13:28:52Z

Ponza Research Station

Fusani Leonida — 2012-05-16T13:26:49Z

Abstracts & Contributions

Fusani Leonida — 2011-09-01T06:00:00Z

Abstract submission is now closed

Abstract submission is closed. If you have been invited by the Scientific Programme Committee to submit an abstract, please prepare it following the instructions below. When you are ready, please proceed to the Abstract Submission Form

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Physiological conditions predict nocturnal restlessness at a stopover site in wild migratory passerines Leonida Fusani1, Wolfgang Goymann2 1Department of Biology and Evolution, University of Ferrara, 44100 Ferrara, Italy, leofusani@gmail.com; 2Max-Planck-Institut for Ornithology, D-82319 Seewiesen, Germany, goymann@orn.mpg.de. During migration a number of bird species rely on stopover sites for recovering and replacing their energy reserves before and after crossing ecological barriers such as desert regions or seas. The duration of the stopover depends on a series of factors including environmental and physiological ones. Previous studies indicated that lean birds prolong their refuelling stopover compared to fat birds, however the quantitative relationship between physiological conditions and stopover behaviour had not been studied yet. We studied whether the amount of migratory restlessness (Zugunruhe) shown at a stopover site depends on physiological conditions in three passerine species, the whinchat Saxicola rubetra, the garden warbler Sylvia borin, and the whitethroat Sylvia communis). A large sample of migrating birds of these three species was caught at a ringing station on the island of Ponza, Italy. After registering a series of morphological and physiological variables, the birds were set in custom-made individual cages with water and food. The cages were equipped with infra-red locomotor activity recorders. The birds were released the following morning. An integrated measure of condition based on body mass, amount of subcutaneous fat, and thickness of pectoral muscles, strongly predicted the intensity of Zugunruhe shown in the recording cages in the night following capture. These results provide novel and robust quantitative evidence in support of the hypothesis that the amount of energy reserves determines the stopover duration in migratory birds.